Avaliação da carga viral de indivíduos com infecção pelo vírus SARS-COV-2 [Digital]
Dissertação
Português
616.98:578.828Covid19
Fortaleza, 2023.
70f.
O SARS-CoV-2 é uma espécie de vírus pertencente à família dos Coronavírus e o responsável pela pandemia por COVID-19. Apresenta elevado índice de transmissibilidade, podendo desenvolver a Síndrome Respiratória Aguda Grave (SRAG), uma das principais consequências clínicas respiratórias que ocorre no...
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O SARS-CoV-2 é uma espécie de vírus pertencente à família dos Coronavírus e o responsável pela pandemia por COVID-19. Apresenta elevado índice de transmissibilidade, podendo desenvolver a Síndrome Respiratória Aguda Grave (SRAG), uma das principais consequências clínicas respiratórias que ocorre no ser humano. Por causa do elevado número de casos em todo mundo e por suas graves complicações clínicas, a Organização Mundial de Saúde (OMS), em fevereiro de 2020, decretou a pandemia por COVID-19. Diante dessa situação, o objetivo dessa pesquisa foi de analisar as cargas virais de indivíduos acometidos de COVID-19 no estado do Ceará no ano de 2020. O estudo foi efetuado na Universidade de Fortaleza no Laboratório de Virologia. Os dados foram inicialmente compostos com 6.229 amostras, destas, 47,00% (2.928) eram do sexo feminino, 44,80% (2.793) do sexo masculino e 8,2% (508) não tinha informação sobre essa variável. Acerca da faixa etária, verificou-se que 4,60% (n = 260) eram crianças, 2,5% (n = 144) eram adolescentes (de 12 até 19 anos), 51,10% (n = 2911) eram adultos (20 até 59 anos) e 41,80% (n = 2377) eram idosos (60 anos ou mais). Avaliando a cidade de origem dos participantes, a maioria era de Fortaleza (63,9%; n = 3695), Sobral (8,10%; n = 467), Quixeramobim (2,40%; n = 141), Quixadá (1,80%; n = 105). Outras cidades, com amostras menores de 100, apresentaram 23,80% (n = 1377) e da amostragem total (N = 6.229), ressalta-se que 7,1% (n = 444) não informou a cidade de origem. Acerca do status, constatou-se que a maioria estava em estado de internação (47,00%; n = 1799) ou em enfermaria (23,40%; n = 897). Porém, destaca-se uma grande quantidade, também, em UTIs (13,80%; n = 527) e em emergência (7,40%; n = 459). Os dados relacionados às cargas virais apresentaram uma média de 27,5 (CT), variando de CT de 8,44 até 39,99, sendo para o sexo masculino em torno de 27,33 e para o feminino de 27,07. No que concerne à faixa etária, observou-se uma média de 31,33 para crianças até 11 anos de idade, para adolescentes 27,66, idade de 12 a 19 anos, adultos de 20 a 59 anos, uma média de 27,47, bem como idosos com acima de 60 anos, média de 26,94. Ademais, relacionaram-se as cargas virais com a função status, sendo em média 27,07 para enfermaria; UTI, 25,22; óbitos, 26,01; emergência, 25,25. Portanto, neste estudo observamos que o SARS-CoV-2 acometeu homens e mulheres de forma equânime, sendo os indivíduos com faixa etária acima de 60 anos mais acometidos, com os índices das cargas virais mais elevadas.
Palavras-chave: COVID-19. Carga Viral. Epidemiologia. Ver menos
Palavras-chave: COVID-19. Carga Viral. Epidemiologia. Ver menos
SARS-CoV-2 is a species of virus belonging to the Coronavirus family and responsible for the COVID-19 pandemic. It has a high rate of transmissibility and may develop Severe Acute Respiratory Syndrome (SARS), one of the main respiratory clinical consequences
that occurs in humans. Because of the... Ver mais SARS-CoV-2 is a species of virus belonging to the Coronavirus family and responsible for the COVID-19 pandemic. It has a high rate of transmissibility and may develop Severe Acute Respiratory Syndrome (SARS), one of the main respiratory clinical consequences
that occurs in humans. Because of the high number of cases worldwide and their serious clinical complications, the World Health Organization (WHO) in February 2020 decreed the COVID-19 pandemic. In view of this situation, the objective of this research was to analyze the viral loads of individuals affected by COVID-19 during the year 2020 in the state of Ceará. The study was carried out at the University of Fortaleza in the Virology Laboratory. Data were initially composed of 6,229 samples, of which 47.00% (2,928) were female, 44.80% (2,793) male and 8.2% (508) had no information about this variable. Regarding the age range, it was found that 4.60% (n = 260) were children, 2.5% (n = 144) were adolescents (from 12 to 19 years old), 51.10 % (n = 2911) were adults (20 to 59 years old) and 41.80% (n = 2377) were elderly (60 years old or older). Evaluating the city of origin of the participants, most were from Fortaleza (63.9%; n = 3695), Sobral (8.10%; n = 467), Quixeramobim (2.40%; n = 141), Quixadá (1.80%; n = 105). Other cities, with samples smaller than 100, presented 23.80% (n = 1377). Of the total sample (N = 6,229), it is noteworthy that 7.1% (n = 444) did not inform the city of origin. Regarding the status, it was found that most were in a state of hospitalization (47.00%; n = 1799) or in the ward (23.40%; n = 897). However, a large number also stands out in ICUs (13.80%; n = 527) and in emergency rooms (7.40%; n = 459). Data related to viral loads showed an average of 27.5 (CT), ranging from CT from 8.44 to 39.99, being around 27.33 for males and 27.07 for females. With regard to age group, there was an average of 31.33 for children up to 11 years old, for adolescents 27.66, aged from 12 to 19 years old, adults from 20 to 59 years old, an average of 27.47, as well as seniors over 60 years old, mean of 26.94. Furthermore, viral loads were related to the status function, with an average of 27.07 for the ward; ICU, 25.22; deaths, 26.01; emergency, 25.25. Therefore, in this study, we observed that SARSCoV-2 affects men and women equally, with individuals aged over 60 years being more affected, with higher viral load rates.
Keywords: COVID-19; Viral charge; Epidemiology. Ver menos
that occurs in humans. Because of the... Ver mais SARS-CoV-2 is a species of virus belonging to the Coronavirus family and responsible for the COVID-19 pandemic. It has a high rate of transmissibility and may develop Severe Acute Respiratory Syndrome (SARS), one of the main respiratory clinical consequences
that occurs in humans. Because of the high number of cases worldwide and their serious clinical complications, the World Health Organization (WHO) in February 2020 decreed the COVID-19 pandemic. In view of this situation, the objective of this research was to analyze the viral loads of individuals affected by COVID-19 during the year 2020 in the state of Ceará. The study was carried out at the University of Fortaleza in the Virology Laboratory. Data were initially composed of 6,229 samples, of which 47.00% (2,928) were female, 44.80% (2,793) male and 8.2% (508) had no information about this variable. Regarding the age range, it was found that 4.60% (n = 260) were children, 2.5% (n = 144) were adolescents (from 12 to 19 years old), 51.10 % (n = 2911) were adults (20 to 59 years old) and 41.80% (n = 2377) were elderly (60 years old or older). Evaluating the city of origin of the participants, most were from Fortaleza (63.9%; n = 3695), Sobral (8.10%; n = 467), Quixeramobim (2.40%; n = 141), Quixadá (1.80%; n = 105). Other cities, with samples smaller than 100, presented 23.80% (n = 1377). Of the total sample (N = 6,229), it is noteworthy that 7.1% (n = 444) did not inform the city of origin. Regarding the status, it was found that most were in a state of hospitalization (47.00%; n = 1799) or in the ward (23.40%; n = 897). However, a large number also stands out in ICUs (13.80%; n = 527) and in emergency rooms (7.40%; n = 459). Data related to viral loads showed an average of 27.5 (CT), ranging from CT from 8.44 to 39.99, being around 27.33 for males and 27.07 for females. With regard to age group, there was an average of 31.33 for children up to 11 years old, for adolescents 27.66, aged from 12 to 19 years old, adults from 20 to 59 years old, an average of 27.47, as well as seniors over 60 years old, mean of 26.94. Furthermore, viral loads were related to the status function, with an average of 27.07 for the ward; ICU, 25.22; deaths, 26.01; emergency, 25.25. Therefore, in this study, we observed that SARSCoV-2 affects men and women equally, with individuals aged over 60 years being more affected, with higher viral load rates.
Keywords: COVID-19; Viral charge; Epidemiology. Ver menos
Lima, Danielle Malta
Orientador
Monteiro, Daniela Cristina Sensato
Banca examinadora
Souza, Natália Vasconcelos de
Banca examinadora
Universidade de Fortaleza. Programa de Pós-Graduação em Ciências Médicas
Dissertação (mestrado)